Publications

Since 2020:

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Histone H2A variants play a key role at DNA double-strand breaks during repair pathway choice.

E. Clerf*, M. Galloy*, A. Fradet-Turcotte# and J. Côté#

Front. Epigenet. Epigenom., 21 August 2024; 2:1445765.

 

Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex.
Yang Z*, Mameri A*, Cattoglio C, Lachance C, Florez Ariza AJ, Luo J, Humbert J, Sudarshan D, Banerjea A, Galloy M, Fradet-Turcotte A, Lambert JP, Ranish JA, Côté J#, Nogales E#.

Science. 2024 Aug 1:eadl5816.

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HBO1, a MYSTerious KAT and its links to cancer.

Yokoyama A, Niida H, Kutateladze TG, Côté J.

Biochim Biophys Acta Gene Regul Mech. 2024 Jun 6;1867(3):195045.

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ASXLs binding to the PHD2/3 fingers of MLL4 provides a mechanism for the recruitment of BAP1 to active enhancers.

Zhang Y*, Xie G*, Lee JE*, Zandian M*, Sudarshan D*, Estavoyer B, Benz C, Viita T, Asgaritarghi G, Lachance C, Messmer C, Simonetti L, Sinha VK, Lambert JP, Chen YW, Wang SP, Ivarsson Y, Affar EB, Côté J#, Ge K#, Kutateladze TG#.

Nat Commun. 2024 Jun 7;15(1):4883.

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The Functional Relationship Between RNA Splicing and the Chromatin Landscape.

Yustis JC, Devoucoux M, Côté J.

J Mol Biol. 2024 May 16:168614.

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Guiding the HBO1 complex function through the JADE subunit.

Gaurav N*, Kanai A*, Lachance C*, Cox KL, Liu J, Grzybowski AT, Saksouk N, Klein BJ, Komata Y, Asada S, Ruthenburg AJ, Poirier MG, Côté J#, Yokoyama A#, Kutateladze TG#.

Nat Struct Mol Biol. 2024 Mar 6;31:1039-1049.

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The immediate-early protein 1 of human herpesvirus 6B interacts with NBS1 and inhibits ATM signaling.

Collin V, Biquand É, Tremblay V, Lavoie ÉG, Blondeau A, Gravel A, Galloy M, Lashgari A, Dessapt J, Côté J, Flamand L, Fradet-Turcotte A.

EMBO Rep. 2024 Feb;25(2):725-744.

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JAZF1: A metabolic actor subunit of the NuA4/TIP60 chromatin modifying complex.

Mameri A, Côté J.

Front Cell Dev Biol. 2023 Apr 7;11:1134268.

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MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain.

Becht DC*, Klein BJ*, Kanai A*, Jang SM*, Cox KL, Zhou BR, Phanor SK, Zhang Y, Chen RW, Ebmeier CC, Lachance C, Galloy M, Fradet-Turcotte A, Bulyk ML, Bai Y, Poirier MG, Côté J#, Yokoyama A#, Kutateladze TG#.

Nat Commun. 2023 Feb 8;14(1):697.

 

The MOZ-BRPF1 acetyltransferase complex in epigenetic crosstalk linked to gene regulation, development, and human diseases.

Viita T, Côté J.

Front Cell Dev Biol. 2023 Jan 11;10:1115903.

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Characterization of multiple interactions between the envelope E protein of SARS-CoV-2 and human BRD4.

Zandian M*, Jang SM*, Lachance C*, Acharya A*, Byrareddy SN#, Côté J#, Kutateladze TG#.

STAR Protoc. 2022 Dec 16;3(4):101853.

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A balancing act: interactions within NuA4/TIP60 regulate picNuA4 function in Saccharomyces cerevisiae and humans.

Lu PYT, Kirlin AC, Aristizabal MJ, Brewis HT, Lévesque N, Setiaputra DT, Avvakumov N, Benschop JJ, Groot Koerkamp M, Holstege FCP, Krogan NJ, Yip CK, Côté J, Kobor MS.

Genetics. 2022 Nov 1;222(3):iyac136.

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Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection.

Vann KR*, Acharya A*, Jang SM*, Lachance C, Zandian M, Holt TA, Smith AL, Pandey K, Durden DL, El-Gamal D, Côté J#, Byrareddy SN#, Kutateladze TG#.

Structure. 2022 Jun 9:S0969-2126(22)00229-5.

 

Recurrent chromosomal translocations in sarcomas create a megacomplex that mislocalizes NuA4/TIP60 to Polycomb target loci.

Sudarshan D, Avvakumov N, Lalonde ME, Alerasool N, Joly-Beauparlant C, Jacquet K, Mameri A, Lambert JP, Rousseau J, Lachance C, Paquet E, Herrmann L, Thonta Setty S, Loehr J, Bernardini MQ, Rouzbahman M, Gingras AC, Coulombe B, Droit A, Taipale M, Doyon Y, Côté J.

Genes Dev. 2022 Jun 1;36(11-12):664-683.

 

Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes.

Devoucoux M, Fort V, Khelifi G, Xu J, Alerasool N, Galloy M, Wong N, Bourriquen G, Fradet-Turcotte A, Taipale M, Hope K, Hussein SMI, Côté J.

Cell Rep. 2022 Jun 14;39(11):110947.

 

MRG Proteins Are Shared by Multiple Protein Complexes With Distinct Functions.

Devoucoux M, Roques C, Lachance C, Lashgari A, Joly-Beauparlant C, Jacquet K, Alerasool N, Prudente A, Taipale M, Droit A, Lambert JP, Hussein SMI, Côté J.

Mol Cell Proteomics. 2022 Jul;21(7):100253.

 

New insights into the DNA repair pathway choice with NuA4/TIP60.

Lashgari A, Kougnassoukou Tchara PE, Lambert JP, Côté J.

DNA Repair (Amst). 2022 Mar 3;113:103315.

 

Rap1 regulates TIP60 function during fate transition between two-cell-like and pluripotent states.

Barry RM, Sacco O, Mameri A, Stojaspal M, Kartsonis W, Shah P, De Ioannes P, Hofr C, Côté J, Sfeir A.

Genes Dev. 2022 Mar 1;36(5-6):313-330.

 

NuA4 and H2A.Z control environmental responses and autotrophic growth in Arabidopsis.

Bieluszewski T*, Sura W*, Dziegielewski W*, Bieluszewska A, Lachance C, Kabza M, Szymanska-Lejman M, Abram M, Wlodzimierz P, De Winne N, De Jaeger G, Sadowski J, Côté J#, Ziolkowski PA#.

Nat Commun. 2022 Jan 12;13(1):277.

 

Approaches to Study Native Chromatin-Modifying Complex Activities and Functions.

Galloy M*, Lachance C*, Cheng X, Distéfano-Gagné F, Côté J#, Fradet-Turcotte A#.

Front Cell Dev Biol. 2021 Sep 16;9:729338.

 

DNA Damage-Induced Phosphorylation of Histone H2A at Serine 15 Is Linked to DNA End Resection.

Ahmad S, Côté V, Côté J.

Mol Cell Biol. 2021 Nov 22;41(12):e0005621.

 

Antagonistic relationship of NuA4 with the non-homologous end-joining machinery at DNA damage sites.

Ahmad S, Côté V, Cheng X, Bourriquen G, Sapountzi V, Altaf M, Côté J.

PLoS Genet. 2021 Sep 20;17(9):e1009816.

 

NuA4 and SAGA acetyltransferase complexes cooperate for repair of DNA breaks by homologous recombination.

Cheng X, Côté V, Côté J.

PLoS Genet. 2021 Jul 6;17(7):e1009459.

 

Structural and biophysical characterization of the nucleosome-binding PZP domain.

Klein BJ, Cox KL, Jang SM, Singh RK, Côté J, Poirier MG, Kutateladze TG.

STAR Protoc. 2021 Apr 19;2(2):100479.

 

The deubiquitylase Ubp15 couples transcription to mRNA export.

Eyboulet F, Jeronimo C, Côté J, Robert F.

Elife. 2020 Nov 23;9:e61264.

 

De Novo KAT5 Variants Cause a Syndrome with Recognizable Facial Dysmorphisms, Cerebellar Atrophy, Sleep Disturbance, and Epilepsy.

Humbert J, Salian S, Makrythanasis P, Lemire G, Rousseau J, Ehresmann S, Garcia T, Alasiri R, Bottani A, Hanquinet S, Beaver E, Heeley J, Smith ACM, Berger SI, Antonarakis SE, Yang XJ, Côté J, Campeau PM.

Am J Hum Genet. 2020 Sep 3;107(3):564-574.

 

JMJD6 participates in the maintenance of ribosomal DNA integrity in response to DNA damage.

Fages J, Chailleux C, Humbert J, Jang SM, Loehr J, Lambert JP, Côté J, Trouche D, Canitrot Y.

PLoS Genet. 2020 Jun 29;16(6):e1008511.

 

Structural Basis for EPC1-Mediated Recruitment of MBTD1 into the NuA4/TIP60 Acetyltransferase Complex.

Zhang H*, Devoucoux M*, Song X, Li L, Ayaz G, Cheng H, Tempel W, Dong C, Loppnau P, Côté J#, Min J#.

Cell Rep. 2020 Mar 24;30(12):3996-4002.e4.

 

Integrated analysis of H2A.Z isoforms function reveals a complex interplay in gene regulation.

Lamaa A, Humbert J, Aguirrebengoa M, Cheng X, Nicolas E, Côté J, Trouche D.

Elife. 2020 Feb 28;9:e53375.

 

Molecular Basis for the PZP Domain of BRPF1 Association with Chromatin.

Klein BJ, Cox KL, Jang SM, Côté J, Poirier MG, Kutateladze TG.

Structure. 2020 Jan 7;28(1):105-110.e3.

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2010-2019: (selected)

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Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation.

Klein BJ*, Jang SM*, Lachance C, Mi W, Lyu J, Sakuraba S, Krajewski K, Wang WW, Sidoli S, Liu J, Zhang Y, Wang X, Warfield BM, Kueh AJ, Voss AK, Thomas T, Garcia BA, Liu WR, Strahl BD, Kono H, Li W, Shi X, Côté J#, Kutateladze TG#.

Nat Commun. 2019 Oct 17;10(1):4724.

 

Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection.

Cheng X, Jobin-Robitaille O, Billon P, Buisson R, Niu H, Lacoste N, Abshiru N, Côté V, Thibault P, Kron SJ, Sung P, Brandl CJ, Masson JY, Côté J.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10028-10033.

 

Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex.

Wang X, Ahmad S, Zhang Z, Côté J, Cai G.

Nat Commun. 2018 Mar 20;9(1):1147.

 

Molecular Architecture of the Essential Yeast Histone Acetyltransferase Complex NuA4 Redefines Its Multimodularity.

Setiaputra D, Ahmad S, Dalwadi U, Steunou AL, Lu S, Ross JD, Dong MQ, Côté J, Yip CK.

Mol Cell Biol. 2018 Apr 16;38(9):e00570-17.

 

Yaf9 subunit of the NuA4 and SWR1 complexes targets histone H3K27ac through its YEATS domain.

Klein BJ*, Ahmad S*, Vann KR, Andrews FH, Mayo ZA, Bourriquen G, Bridgers JB, Zhang J, Strahl BD, Côté J#, Kutateladze TG#.

Nucleic Acids Res. 2018 Jan 9;46(1):421-430.

 

Acetylation of PCNA Sliding Surface by Eco1 Promotes Genome Stability through Homologous Recombination.

Billon P, Li J, Lambert JP, Chen Y, Tremblay V, Brunzelle JS, Gingras AC, Verreault A, Sugiyama T, Couture JF, Côté J.

Mol Cell. 2017 Jan 5;65(1):78-90.

 

Combined Action of Histone Reader Modules Regulates NuA4 Local Acetyltransferase Function but Not Its Recruitment on the Genome.

Steunou AL, Cramet M, Rossetto D, Aristizabal MJ, Lacoste N, Drouin S, Côté V, Paquet E, Utley RT, Krogan N, Robert F, Kobor MS, Côté J.

Mol Cell Biol. 2016 Oct 28;36(22):2768-2781.

 

The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation.

Jacquet K, Fradet-Turcotte A, Avvakumov N, Lambert JP, Roques C, Pandita RK, Paquet E, Herst P, Gingras AC, Pandita TK, Legube G, Doyon Y, Durocher D, Côté J.

Mol Cell. 2016 May 5;62(3):409-421.

 

BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation.

Feng Y*, Vlassis A*, Roques C*, Lalonde ME, González-Aguilera C, Lambert JP, Lee SB, Zhao X, Alabert C, Johansen JV, Paquet E, Yang XJ, Gingras AC, Côté J#, Groth A#.

EMBO J. 2016 Jan 18;35(2):176-92.

 

A Scalable Genome-Editing-Based Approach for Mapping Multiprotein Complexes in Human Cells.

Dalvai M, Loehr J, Jacquet K, Huard CC, Roques C, Herst P, Côté J, Doyon Y.

Cell Rep. 2015 Oct 20;13(3):621-633.

 

Eaf5/7/3 form a functionally independent NuA4 submodule linked to RNA polymerase II-coupled nucleosome recycling.

Rossetto D, Cramet M, Wang AY, Steunou AL, Lacoste N, Schulze JM, Côté V, Monnet-Saksouk J, Piquet S, Nourani A, Kobor MS, Côté J.

EMBO J. 2014 Jun 17;33(12):1397-415.

 

Histone target selection within chromatin: an exemplary case of teamwork.

Lalonde ME, Cheng X, Côté J.

Genes Dev. 2014 May 15;28(10):1029-41.

 

Regulating Chromatin by Histone Acetylation.

Steunou, AL., Rossetto, D., Côté, J. (2014).

In: Workman, J., Abmayr, S. (eds) Fundamentals of Chromatin. Springer, New York, NY.

 

Precise deposition of histone H2A.Z in chromatin for genome expression and maintenance.

Billon P, Côté J.

Biochim Biophys Acta. 2013 Mar-Apr;1819(3-4):290-302.

 

Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity.

Lalonde ME, Avvakumov N, Glass KC, Joncas FH, Saksouk N, Holliday M, Paquet E, Yan K, Tong Q, Klein BJ, Tan S, Yang XJ, Kutateladze TG, Côté J.

Genes Dev. 2013 Sep 15;27(18):2009-24.

 

Perceiving the epigenetic landscape through histone readers.

Musselman CA, Lalonde ME, Côté J, Kutateladze TG.

Nat Struct Mol Biol. 2012 Dec;19(12):1218-27.

 

Histone phosphorylation: a chromatin modification involved in diverse nuclear events.

Rossetto D, Avvakumov N, Côté J.

Epigenetics. 2012 Oct;7(10):1098-108.

 

Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation.

Avvakumov N, Lalonde ME, Saksouk N, Paquet E, Glass KC, Landry AJ, Doyon Y, Cayrou C, Robitaille GA, Richard DE, Yang XJ, Kutateladze TG, Côté J.

Mol Cell Biol. 2012 Feb;32(3):689-703.

 

Structure and nucleosome interaction of the yeast NuA4 and Piccolo-NuA4 histone acetyltransferase complexes.

Chittuluru JR, Chaban Y, Monnet-Saksouk J, Carrozza MJ, Sapountzi V, Selleck W, Huang J, Utley RT, Cramet M, Allard S, Cai G, Workman JL, Fried MG, Tan S, Côté J#, Asturias FJ#.

Nat Struct Mol Biol. 2011 Oct 9;18(11):1196-203.

 

Histone chaperones: modulators of chromatin marks.

Avvakumov N, Nourani A, Côté J.

Mol Cell. 2011 Mar 4;41(5):502-14.

 

NuA4-dependent acetylation of nucleosomal histones H4 and H2A directly stimulates incorporation of H2A.Z by the SWR1 complex.

Altaf M, Auger A, Monnet-Saksouk J, Brodeur J, Piquet S, Cramet M, Bouchard N, Lacoste N, Utley RT, Gaudreau L, Côté J.

J Biol Chem. 2010 May 21;285(21):15966-77.

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Before 2010: (selected)

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HBO1 HAT complexes target chromatin throughout gene coding regions via multiple PHD finger interactions with histone H3 tail.

Saksouk N, Avvakumov N, Champagne KS, Hung T, Doyon Y, Cayrou C, Paquet E, Ullah M, Landry AJ, Côté V, Yang XJ, Gozani O, Kutateladze TG, Côté J.

Mol Cell. 2009 Jan 30;33(2):257-65.

 

Eaf1 is the platform for NuA4 molecular assembly that evolutionarily links chromatin acetylation to ATP-dependent exchange of histone H2A variants.

Auger A, Galarneau L, Altaf M, Nourani A, Doyon Y, Utley RT, Cronier D, Allard S, Côté J.

Mol Cell Biol. 2008 Apr;28(7):2257-70.

 

Interplay of chromatin modifiers on a short basic patch of histone H4 tail defines the boundary of telomeric heterochromatin.

Altaf M, Utley RT, Lacoste N, Tan S, Briggs SD, Côté J.

Mol Cell. 2007 Dec 28;28(6):1002-14.

 

New nomenclature for chromatin-modifying enzymes.

Allis CD, Berger SL, Cote J, Dent S, Jenuwien T, Kouzarides T, Pillus L, Reinberg D, Shi Y, Shiekhattar R, Shilatifard A, Workman J, Zhang Y.

Cell. 2007 Nov 16;131(4):633-6.

 

ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.

Doyon Y, Cayrou C, Ullah M, Landry AJ, Côté V, Selleck W, Lane WS, Tan S, Yang XJ, Côté J.

Mol Cell. 2006 Jan 6;21(1):51-64.

 

A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16.

Smith ER, Cayrou C, Huang R, Lane WS, Côté J, Lucchesi JC.

Mol Cell Biol. 2005 Nov;25(21):9175-88.

 

Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites.

Downs JA*, Allard S*, Jobin-Robitaille O, Javaheri A, Auger A, Bouchard N, Kron SJ, Jackson SP, Côté J.

Mol Cell. 2004 Dec 22;16(6):979-90.

 

The highly conserved and multifunctional NuA4 HAT complex.

Doyon Y, Côté J.

Curr Opin Genet Dev. 2004 Apr;14(2):147-54.

 

Recruitment of the NuA4 complex poises the PHO5 promoter for chromatin remodeling and activation.

Nourani A, Utley RT, Allard S, Côté J.

EMBO J. 2004 Jul 7;23(13):2597-607.

 

Cellular machineries for chromosomal DNA repair.

Peterson CL, Côté J.

Genes Dev. 2004 Mar 15;18(6):602-16.

 

Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.

Doyon Y, Selleck W, Lane WS, Tan S, Côté J.

Mol Cell Biol. 2004 Mar;24(5):1884-96.

 

The diverse functions of histone acetyltransferase complexes.

Carrozza MJ, Utley RT, Workman JL, Côté J.

Trends Genet. 2003 Jun;19(6):321-9.

 

Yeast enhancer of polycomb defines global Esa1-dependent acetylation of chromatin.

Boudreault AA, Cronier D, Selleck W, Lacoste N, Utley RT, Allard S, Savard J, Lane WS, Tan S, Côté J.

Genes Dev. 2003 Jun 1;17(11):1415-28.

 

Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase.

Lacoste N, Utley RT, Hunter JM, Poirier GG, Côte J.

J Biol Chem. 2002 Aug 23;277(34):30421-4.

 

Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription.

Galarneau L, Nourani A, Boudreault AA, Zhang Y, Héliot L, Allard S, Savard J, Lane WS, Stillman DJ, Côté J.

Mol Cell. 2000 Jun;5(6):927-37.

 

NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p.

Allard S, Utley RT, Savard J, Clarke A, Grant P, Brandl CJ, Pillus L, Workman JL, Côté J.

EMBO J. 1999 Sep 15;18(18):5108-19.

 

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Pre-historical: (selected)

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Perturbation of nucleosome core structure by the SWI/SNF complex persists after its detachment, enhancing subsequent transcription factor binding.

Côté J, Peterson CL, Workman JL.

Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):4947-52.

 

Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.

Grant PA, Duggan L, Côté J, Roberts SM, Brownell JE, Candau R, Ohba R, Owen-Hughes T, Allis CD, Winston F, Berger SL, Workman JL.

Genes Dev. 1997 Jul 1;11(13):1640-50.

 

Purification and biochemical heterogeneity of the mammalian SWI-SNF complex.

Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR.

EMBO J. 1996 Oct 1;15(19):5370-82.

 

Stimulation of GAL4 derivative binding to nucleosomal DNA by the yeast SWI/SNF complex.

Côté J, Quinn J, Workman JL, Peterson CL.

Science. 1994 Jul 1;265(5168):53-60.

 

Primers for mitochondrial DNA replication generated by endonuclease G.

Côté J, Ruiz-Carrillo A.

Science. 1993 Aug 6;261(5122):765-9.