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Research & Discoveries

Current Areas of Study

Chromatin modifying complexes

Protein complexes conserved from yeast to humans harboring MYST-family histone acetyltransferase and ING-family tumor suppressor subunits


The NuA4/TIP60 complex: an essential multifunctional player in epigenetic mechanisms

A haplo-insufficient Tumor Suppressor, the NuA4/TIP60 complex is essential for cell viability, stem cell renewal, gene-specific activation and repair of DNA damage.  It is a large multisubunit protein complex with two enzymatic activities implicated in epigenetic mechanisms, histone acetylation and incoporation of the histone variant H2A.Z.  In addition, it contains a plethora of reader modules capable to decipher epigenetic signals on chromatin.


Experimental approaches

Biochemistry of chromatin and protein complexes, protein-protein and DNA-protein interactions, native purification, Molecular Biology and Genetics, Mutagenesis, Genome editing, Proteomics, Functional Genomics (RNA-seq, ChIP-seq, CUTnRUN-seq)

Image by National Cancer Institute
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